AMMD
Methylation Support®
79/100
SUPPIE SCORE
78/100
EFFICACY
Medium
SAFETY
98/100
CLEANLINESS
What Does Methylation Support® Do?
Amy Myers MD Methylation Support combines active B vitamins and trimethylglycine to effectively reduce elevated homocysteine in individuals with MTHFR gene variants, though its very high folate dose substantially exceeds standard requirements.
How does L-5-MTHF differ from regular folic acid for someone with an MTHFR variant?
Can taking high amounts of methyl donors cause anxiety or insomnia?
Should I monitor my homocysteine and B12 levels while taking Methylation Support?
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What Are the Benefits of Methylation Support®?
Based on proven scientific research
Homocysteine ReductionStrong
MTHFR Variant Nutritional SupportStrong
Folate and B12 Status CorrectionStrong
Cellular Methylation Cycle SupportModerate
Good For:
What Are the Side Effects of AMMD Methylation Support®?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Folate: 3,500 mcg a day is over the 1,000 mcg/day upper limit (IOM (NIH ODS)) (about 3.5 times the limit). Folic acid above this limit can mask vitamin B12 deficiency.
•The daily serving delivers 2,100 mcg of L-5-MTHF (3,500 mcg DFE), which exceeds the established upper intake level for synthetic folic acid (1,000 mcg/day) and can mask hematologic signs of vitamin B12 deficiency if taken without adequate B12 monitoring.
•Supplies 10 mg of vitamin B6 as pyridoxal-5-phosphate, which approaches the European Food Safety Authority tolerable upper limit of 12 mg/day.
•Rapid introduction of 1,000 mg trimethylglycine and methylated vitamins can trigger overmethylation symptoms such as irritability, headaches, or palpitations in sensitive individuals.
•High supplemental betaine intake may slightly elevate serum LDL cholesterol and triglyceride levels in some individuals during long-term use.
•Pregnant or nursing individuals should consult their clinician before use due to the supra-physiological doses of active folate and coenzyme B vitamins.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Hypromellose (vegetable capsule)
Low RiskL-leucine
Low RiskWhat Are the Ingredients in AMMD Methylation Support®?
Vitamin B2 (as Riboflavin 5'-Phosphate)
20mg
Vitamin B6 (as Pyridoxal-5-Phosphate)
10mg
Folate (as Magnafolate®-C Calcium L-5-Methyltetrahydrofolate)
3500mcg DFE
Vitamin B12 (as Methylcobalamin)
1000mcg
Trimethylglycine (TMG)
1000mg
Hypromellose (vegetable capsule)
L-leucine
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Dosage & Bioavailability
How the active doses and forms in Methylation Support® compare to the research.
•Formula — 5 actives: 1 over its upper limit (folate), 1 below studied amounts (trimethylglycine) and 3 within studied amounts (vitamin B2, vitamin B6 and vitamin B12).
•Folate (as Magnafolate®-C Calcium L-5-Methyltetrahydrofolate) — 3,500 mcg a day is over the 1,000 mcg/day upper limit (IOM (NIH ODS)).
•Vitamins and minerals — 4 of 4 provide at least 90% of the daily reference intake: vitamin B12 (about 400 times), vitamin B2 (about 14 times), folate (about 8 times) and vitamin B6 (about 5 times).
Sources & References
Frequently Asked Questions
Common questions about AMMD Methylation Support®