Codeage
Methylfolate B Complex+
89/100
SUPPIE SCORE
88/100
EFFICACY
High
SAFETY
90/100
CLEANLINESS
What Does Methylfolate B Complex+ Do?
This well-formulated methylated B complex excels in supporting methylation with bioavailable forms and optimal dosages backed by strong evidence from RCTs and meta-analyses. Highly safe for most adults with minimal risks.
What are the benefits of methylated B vitamins like 5-MTHF for MTHFR gene variants?
How does this supplement support methylation and homocysteine levels?
Is this B complex suitable for vegans and what dosage is recommended?
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What Are the Benefits of Methylfolate B Complex+?
Based on proven scientific research
Supports methylation processVery strong
Promotes healthy homocysteine levelsStrong
Aids energy metabolismStrong
Supports cognitive functionModerate
Good For:
What Are the Side Effects of Codeage Methylfolate B Complex+?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•All active ingredients are at dosages well within safe upper limits established by NIH and EFSA, with no exceedances for healthy adults.
•Methylated forms reduce risks associated with unmetabolized folic acid; suitable for MTHFR variants but monitor in those with B12 deficiency to avoid masking.
•Low interaction potential with common medications, though high B12 may interact with metformin or PPIs; consult physician if on anticonvulsants.
•Vegan formulation free of major allergens; safe for pregnancy at recommended doses but consult healthcare provider for folate needs.
•No reported manufacturing issues; produced in cGMP-certified facility with third-party testing for purity and contaminants.
•Long-term use generally safe, but periodic monitoring of B-vitamin levels advised to prevent imbalances in sensitive individuals.
Potential Side Effects
Negative Interactions
Allergens
None identified
Inactive Ingredients
Microcrystalline cellulose
Low RiskMagnesium stearate
Low RiskHypromellose (vegetable capsule)
Low RiskSilicon dioxide
Low RiskWhat Are the Ingredients in Codeage Methylfolate B Complex+?
Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt
1,360 mcg DFE
Riboflavin (as Riboflavin 5-Phosphate Sodium)
25 mg
Vitamin B6 (as Pyridoxal 5-Phosphate)
20 mg
Folate (as L-5-Methyltetrahydrofolate calcium)
400 mcg DFE
Vitamin B12 (as Methylcobalamin)
1,000 mcg
Betaine Anhydrous (Trimethylglycine)
600 mg
Microcrystalline Cellulose
Magnesium Stearate
Hypromellose (vegetable capsule)
Silicon Dioxide
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Dosage & Bioavailability
How the active doses and forms in Methylfolate B Complex+ compare to the research.
•Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt — 1,360 mcg per serving is over the 1,000 mcg/day upper limit (IOM (NIH ODS)).
•Vitamin B6 (as Pyridoxal 5-Phosphate) — 20 mg per serving is over the 12 mg/day upper limit (EFSA 2023); the US limit is 100 mg/day (IOM (NIH ODS)).
•Riboflavin (as Riboflavin 5-Phosphate Sodium) — 25 mg per serving; within the 1.6-400 mg/day typically used in studies. This range is provisional until reviewed.
Frequently Asked Questions
Common questions about Codeage Methylfolate B Complex+