ENZYMEDICA
Joint
88/100
SUPPIE SCORE
75/100
EFFICACY
High
SAFETY
96/100
CLEANLINESS
What Does Joint Do?
Single active is 300 mg Cronilief PEA phytosome delivering palmitoylethanolamide; meta-analyses support efficacy for chronic pain reduction at 300–1200 mg/day doses with consistent tolerability across trials.
How does the 300 mg PEA phytosome dose compare to typical study ranges?
What evidence supports PEA for joint comfort specifically?
Are there any known interactions with common medications for this ingredient?
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What Are the Benefits of Joint?
Based on proven scientific research
Chronic pain reductionStrong
Joint discomfort reliefModerate
Inflammation modulationModerate
Functional status improvementModerate
Good For:
What Are the Side Effects of ENZYMEDICA Joint?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•Doses of 300–1200 mg/day PEA show good tolerability in trials with no major side effects reported.
•Evidence is limited on long-term use beyond 120 days or specific pregnancy data.
•Phytosome form with lecithin may alter absorption profile compared to standard PEA.
•No major drug interactions documented in available reviews, but individual responses vary.
Potential Side Effects
Negative Interactions
Allergens
Sunflower lecithin presentRice-derived excipients
Inactive Ingredients
Rice hulls
Low RiskVegetarian capsule (hypromellose)
Low RiskRice extract blend (rice extract, rice hulls, gum arabic, sunflower oil)
Low RiskWhat Are the Ingredients in ENZYMEDICA Joint?
Cronilief™ PEA Phytosome® (palmitoylethanolamide, sunflower lecithin, microcrystalline cellulose) % DV
300 mg
Rice hulls
vegetarian capsule (hypromellose)
rice extract blend (rice extract, rice hulls, gum arabic, sunflower oil)
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Dosage & Bioavailability
How the active doses and forms in Joint compare to the research.
•Cronilief™ PEA Phytosome® (palmitoylethanolamide) — 300 mg; within the lower end of the 300–1200 mg/day ranges used in pain trials.
•Cronilief™ PEA Phytosome® (palmitoylethanolamide) — 300 mg; phytosome complex with sunflower lecithin may enhance solubility and absorption relative to uncomplexed PEA.
Sources & References
Joint and muscle
Information from enzymedica.com
Muscle joint comfort
Information from enzymedica.com
Joint support
Information from www.vitaminshoppe.com
PMC11354262
Information from pmc.ncbi.nlm.nih.gov
PMC5094513
Information from pmc.ncbi.nlm.nih.gov
PMC12937724
Information from pmc.ncbi.nlm.nih.gov
PMC10053226
Information from pmc.ncbi.nlm.nih.gov
PMC9414729
Information from pmc.ncbi.nlm.nih.gov
Frequently Asked Questions
Common questions about ENZYMEDICA Joint