Holtmore
nattokinase
71/100
SUPPIE SCORE
60/100
EFFICACY
Medium
SAFETY
90/100
CLEANLINESS
What Does nattokinase Do?
Nattokinase at high activity demonstrates fibrinolytic and vascular effects in trials, but accompanying botanicals and CoQ10 are tucked into an undisclosed proprietary blend.
Is it safe to take nattokinase alongside blood thinners or aspirin?
Should I take nattokinase with food or on an empty stomach?
Why does this formula combine nattokinase with a proprietary herbal blend?
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What Are the Benefits of nattokinase?
Based on proven scientific research
Fibrinolytic and blood flow supportMild
Blood pressure reductionMild
Arterial plaque and lipid modulationMild
Good For:
What Are the Side Effects of Holtmore nattokinase?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Nattokinase dose unknown (no FU activity stated); typical effective doses in trials are 2,000-10,800 FU/day—verify label activity before use.
•Aged garlic extract can modestly lower blood pressure and lipids; monitor if on antihypertensives or anticoagulants.
•Bromelain and pine bark extract may add to bleeding risk with anticoagulants or antiplatelets; space doses if needed.
•Stop and get advice if: unusual bleeding, bruising, or prolonged clotting times: stop and seek medical advice.
•Stop and get advice if: signs of liver issues (jaundice, dark urine) or allergic reaction: discontinue immediately.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Rice flour
Low RiskMagnesium stearate
Low RiskSilicon dioxide
Low RiskVegetable cellulose (capsule)
Low RiskWhat Are the Ingredients in Holtmore nattokinase?
Nattokinase (from natto extract)
500 mg
Proprietary Blend
500 mg
CoQ10 (as ubiquinone)
Turmeric Extract (Curcuma Longa) (root)
Dandelion Root Extract (Taraxacum officinale) (root)
Aged Garlic Extract (Allium sativum) (bulb)
Grape Seed Extract (Vitis vinifera) (seed)
Bromelain (2,400 GDU/g) (from Pineapple Extract) (Ananas comosus) (stem)
10 mg
Pine Bark Extract (Pinus pinaster) (bark)
5 mg
Rice flour
magnesium stearate
silicon dioxide
vegetable cellulose (capsule)
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Dosage & Bioavailability
How the active doses and forms in nattokinase compare to the research.
•Nattokinase (from natto extract) — 500 mg a day; studies use 60-400 mg/day. Above studied amounts is not the same as unsafe.
•Bromelain (2,400 GDU/g) (from Pineapple Extract) (Ananas comosus) (stem) — 10 mg a day; studies use 240-3,200 mg/day.
•2 of 3 actives with a studied range are below it and 6 have no individual amount disclosed.
Sources & References
Nattokinase
Information from holtmore.com
Holtmore nattokinase 10 000 fu extra bottle
Information from holtmore.com
First order one time bonus holtmore nattokinase 10 000 fu
Information from holtmore.com
PMC11266782
Information from pmc.ncbi.nlm.nih.gov
39076715
Information from pubmed.ncbi.nlm.nih.gov
PMC9441630
Information from pmc.ncbi.nlm.nih.gov
PMC12564107
Information from pmc.ncbi.nlm.nih.gov
PMC7261374
Information from ncbi.nlm.nih.gov
Frequently Asked Questions
Common questions about Holtmore nattokinase