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Life Extension - MacuGuard® Ocular Support with Saffron & Astaxanthin

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Life Extension

MacuGuard® Ocular Support with Saffron & Astaxanthin

Life Extension MacuGuard® Ocular Support with Saffron & Astaxanthin
B grade
84/100
SUPPIE SCORE
78/100
EFFICACY
High
SAFETY
84/100
CLEANLINESS

What Does MacuGuard® Ocular Support with Saffron & Astaxanthin Do?

Label provides 4 mg lutein plus 1.24 mg meso-zeaxanthin/zeaxanthin within a 208 mg proprietary blend, 20 mg saffron extract, and 6 mg algal astaxanthin.
How does the lutein and zeaxanthin in this formula compare to doses used in AREDS2 or similar eye health trials?
What evidence supports saffron extract at 20 mg for macular pigment or visual function?
Is 6 mg astaxanthin from algae a typical studied dose for ocular support?
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What Are the Benefits of MacuGuard® Ocular Support with Saffron & Astaxanthin?

Based on proven scientific research

Macular pigment densityStrong
Visual function in AMDModerate
Retinal responseModerate
Photostress recoveryMild

Good For:

What Are the Side Effects of Life Extension MacuGuard® Ocular Support with Saffron & Astaxanthin?

Always consult your health practitioner if in doubt.

RiskLow Risk

Overview

•Lutein and zeaxanthin at these levels show no adverse ocular effects in primate and human trials up to much higher doses.
•Saffron 20 mg daily produced no serious adverse events in 12-month AMD studies.
•Astaxanthin 6 mg from algae has been used without reported issues in visual function trials.
•Carotenoid supplements may interact with bile acid sequestrants or orlistat by reducing absorption.
•Evidence on use in pregnancy is limited; standard label precautions apply.

Potential Side Effects

Negative Interactions

Allergens

Marigold flower extract sourceGelatin capsule shellBeeswax component

Inactive Ingredients

Extra virgin olive oil
Good
Gelatin
Low Risk
Glycerin
Low Risk
Sunflower oil
Low Risk
Purified water
Low Risk
Palm oil
Low Risk
Beeswax
Low Risk
Acacia gum
Good
Maltodextrin
Low Risk
Annatto color
Low Risk

What Are the Ingredients in Life Extension MacuGuard® Ocular Support with Saffron & Astaxanthin?

MacuGuard® proprietary blend
208 mg
Marigold extract (Tagetes erecta ) (flower) [providing
10 mg
lutein
4 mg
meso -zeaxanthin & zeaxanthin], phospholipids, mixed carotenoids [providing
1.24 mg
α-carotene] Saffron extract (stigma)
20 mg
Natural astaxanthin [from CO2 extract of Haematococcus pluvialis algae]
6 mg
extra virgin olive oil
gelatin
glycerin
sunflower oil
purified water
palm oil
beeswax
acacia gum
maltodextrin
annatto color

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Dosage & Bioavailability

How the active doses and forms in MacuGuard® Ocular Support with Saffron & Astaxanthin compare to the research.

•Lutein — 4 mg; within 5–20 mg/day range associated with MPOD increases in meta-analyses of healthy and AMD subjects.
•Saffron extract (stigma) — 20 mg; matches dose used in 12-month trials demonstrating mfERG improvements in AMD participants.

Sources & References

Macuguard ocular support with saffron astaxanthin
Information from www.lifeextension.com
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PMC8634499
Information from pmc.ncbi.nlm.nih.gov
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PMC9655540
Information from pmc.ncbi.nlm.nih.gov
↗
PMC9899915
Information from pmc.ncbi.nlm.nih.gov
↗
PMC4706936
Information from pmc.ncbi.nlm.nih.gov
↗
PMC4698241
Information from pmc.ncbi.nlm.nih.gov
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Frequently Asked Questions

Common questions about Life Extension MacuGuard® Ocular Support with Saffron & Astaxanthin