Life Extension
SAMe 400 mg
72/100
SUPPIE SCORE
82/100
EFFICACY
Medium
SAFETY
76/100
CLEANLINESS
What Does SAMe 400 mg Do?
SAMe 400 mg lists S-Adenosyl-Methionine (400 mg) as its main active. Any judgement should be based on the stated amounts and forms rather than the product name or marketing claims alone.
How does the 400 mg SAMe dosage compare to clinical studies for mood support?
Why is it recommended to take SAMe with B vitamins like B6, B12, and folic acid?
What makes the enteric coating important for SAMe absorption?
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What Are the Benefits of SAMe 400 mg?
Based on proven scientific research
Mood SupportStrong
Joint HealthStrong
Liver SupportModerate
Good For:
What Are the Side Effects of Life Extension SAMe 400 mg?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Avoid if diagnosed with bipolar disorder due to mania risk
•May interact with antidepressants and serotonergic drugs
•Take on empty stomach for optimal absorption
•Generally well-tolerated at recommended doses
•Consult physician if pregnant or lactating
•No major allergen concerns identified
Potential Side Effects
Negative Interactions
Inactive Ingredients
Cellulose
Low RiskMethacrylic acid copolymer
Low RiskMannitol
Low RiskCitric acid
Low RiskStearic acid
Low RiskSilica
Low RiskHypromellose
Low RiskGlyceryl triacetate
Low RiskSodium starch glycolate
Low RiskCroscarmellose sodium
Low RiskCalcium carbonate
Low RiskYellow ochre
Low RiskWhat Are the Ingredients in Life Extension SAMe 400 mg?
S-Adenosyl-Methionine
400 mg
cellulose
methacrylic acid copolymer
mannitol
citric acid
stearic acid
silica
hypromellose
glyceryl triacetate
sodium starch glycolate
croscarmellose sodium
calcium carbonate
yellow ochre
Dosage & Bioavailability
How the active doses and forms in SAMe 400 mg compare to the research.
•S-Adenosyl-Methionine is listed at 400 mg per serving; without a source-specific reference range, dose adequacy cannot be graded.
•S-Adenosyl-Methionine has no distinct chemical or delivery form stated, so no product-specific absorption advantage can be established.
Sources & References
Frequently Asked Questions
Common questions about Life Extension SAMe 400 mg