Life Extension
SAMe 400 mg
48/100
SUPPIE SCORE
82/100
EFFICACY
Medium
SAFETY
34/100
CLEANLINESS
What Does SAMe 400 mg Do?
• 400 mg SAMe dose aligns with many mood and joint studies.
• Enteric coating protects SAMe from stomach acid degradation.
• Recommendation to pair with B6, B12, and folate supports methylation pathways.
How does the 400 mg SAMe dosage compare to clinical studies for mood support?
Why is it recommended to take SAMe with B vitamins like B6, B12, and folic acid?
What makes the enteric coating important for SAMe absorption?
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What Are the Benefits of SAMe 400 mg?
Based on proven scientific research
Mood SupportStrong
Joint HealthStrong
Liver SupportModerate
Good For:
What Are the Side Effects of Life Extension SAMe 400 mg?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Avoid if diagnosed with bipolar disorder due to mania risk
•May interact with antidepressants and serotonergic drugs
•Take on empty stomach for optimal absorption
•Generally well-tolerated at recommended doses
•Consult physician if pregnant or lactating
•No major allergen concerns identified
Potential Side Effects
Negative Interactions
Inactive Ingredients
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
Good
Low Risk
Low Risk
Low Risk
What Are the Ingredients in Life Extension SAMe 400 mg?
S-Adenosyl-Methionine
400 mg
cellulose
methacrylic acid copolymer
mannitol
citric acid
stearic acid
silica
hypromellose
glyceryl triacetate
sodium starch glycolate
croscarmellose sodium
calcium carbonate
yellow ochre
Sources & References
Frequently Asked Questions
Common questions about Life Extension SAMe 400 mg