Life Extension
SAMe 400 mg
70/100
SUPPIE SCORE
82/100
EFFICACY
Medium
SAFETY
72/100
CLEANLINESS
What Does SAMe 400 mg Do?
Its main active, S-Adenosyl-Methionine, provides 400 mg per serving, within the studied range (400-1,200 mg/day).
How does the 400 mg SAMe dosage compare to clinical studies for mood support?
Why is it recommended to take SAMe with B vitamins like B6, B12, and folic acid?
What makes the enteric coating important for SAMe absorption?
Chat with Suppie
What Are the Benefits of SAMe 400 mg?
Based on proven scientific research
Mood SupportStrong
Joint HealthStrong
Liver SupportModerate
Good For:
What Are the Side Effects of Life Extension SAMe 400 mg?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Avoid if diagnosed with bipolar disorder due to mania risk
•May interact with antidepressants and serotonergic drugs
•Take on empty stomach for optimal absorption
•Generally well-tolerated at recommended doses
•Consult physician if pregnant or lactating
•No major allergen concerns identified
Potential Side Effects
Negative Interactions
Inactive Ingredients
Cellulose
Low RiskMethacrylic acid copolymer
Low RiskMannitol
Low RiskCitric acid
Low RiskStearic acid
Low RiskSilica
Low RiskHypromellose
Low RiskGlyceryl triacetate
Low RiskSodium starch glycolate
Low RiskCroscarmellose sodium
Low RiskCalcium carbonate
Low RiskYellow ochre
Low RiskWhat Are the Ingredients in Life Extension SAMe 400 mg?
S-Adenosyl-Methionine
400 mg
cellulose
methacrylic acid copolymer
mannitol
citric acid
stearic acid
silica
hypromellose
glyceryl triacetate
sodium starch glycolate
croscarmellose sodium
calcium carbonate
yellow ochre
Scan the bottle in your cupboard
Same graded report you just read — on any label, in about 10 seconds.
Dosage & Bioavailability
How the active doses and forms in SAMe 400 mg compare to the research.
•400 mg SAMe dose aligns with many mood and joint studies.
•Enteric coating protects SAMe from stomach acid degradation.
•Recommendation to pair with B6, B12, and folate supports methylation pathways.
Sources & References
Frequently Asked Questions
Common questions about Life Extension SAMe 400 mg