Merck
Janumet 50 mg/500 mg Tablets
66/100
SUPPIE SCORE
95/100
EFFICACY
Medium
SAFETY
52/100
CLEANLINESS
What Does Janumet 50 mg/500 mg Tablets Do?
Janumet's 50 mg sitagliptin and 500 mg metformin dosages align with clinical guidelines for effective type 2 diabetes control, supported by strong RCT evidence for HbA1c reduction. Medium safety risk due to GI side effects and lactic acidosis potential in renal patients.
What are the primary benefits of sitagliptin and metformin for type 2 diabetes management?
How does the combination in Janumet improve glycemic control compared to monotherapy?
What monitoring is recommended for patients taking Janumet long-term?
Chat with Suppie
What Are the Benefits of Janumet 50 mg/500 mg Tablets?
Based on proven scientific research
Glycemic controlVery strong
HbA1c reductionVery strong
Blood glucose loweringVery strong
Type 2 diabetes managementVery strong
Good For:
What Are the Side Effects of Merck Janumet 50 mg/500 mg Tablets?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Sitagliptin at 50 mg and metformin at 500 mg are within established safe daily limits for type 2 diabetes treatment, with low risk of hypoglycemia when used as monotherapy or in combination.
•Potential side effects include gastrointestinal issues from metformin (e.g., nausea, diarrhea) and rare hypersensitivity reactions to sitagliptin; monitor renal function as metformin is contraindicated in severe renal impairment.
•Drug interactions include increased risk of lactic acidosis with metformin when combined with iodinated contrast or certain medications like topiramate; sitagliptin has minimal interactions but caution with CYP3A4 inducers.
•Not recommended during pregnancy or breastfeeding due to potential fetal risks from metformin and limited data on sitagliptin; safe for most adults but requires dose adjustment in elderly with renal decline.
•No major allergen risks from active ingredients, but check for sensitivities to excipients like titanium dioxide; long-term use requires periodic monitoring for vitamin B12 deficiency from metformin.
•High-quality manufacturing by Merck minimizes contamination risks, but adhere to prescribed dosing to avoid overdose-related adverse effects like severe lactic acidosis.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
What Are the Ingredients in Merck Janumet 50 mg/500 mg Tablets?
Sitagliptin
50 mg
Metformin HCl
500 mg
Microcrystalline cellulose
Povidone
Sodium lauryl sulfate
Magnesium stearate
Hypromellose
Titanium dioxide
Red iron oxide
Macrogol
Sources & References
Frequently Asked Questions
Common questions about Merck Janumet 50 mg/500 mg Tablets