Metagenics
Activated B's & Folate
72/100
SUPPIE SCORE
75/100
EFFICACY
Medium
SAFETY
82/100
CLEANLINESS
What Does Activated B's & Folate Do?
This well-formulated supplement with active B vitamins effectively supports methylation and homocysteine reduction for cardiovascular benefits, backed by strong evidence. Dosages are mostly optimal, though high B6 warrants caution for potential neuropathy. Overall safe for targeted use under guidance.
How does methylated folate benefit individuals with MTHFR mutations?
What role does serine play in supporting methylation processes?
Are active forms of B vitamins more effective than standard forms for cardiovascular health?
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What Are the Benefits of Activated B's & Folate?
Based on proven scientific research
Cardiovascular HealthStrong
Homocysteine ReductionVery strong
Methylation SupportVery strong
Stress ReliefModerate
Cognitive FunctionModerate
Good For:
What Are the Side Effects of Metagenics Activated B's & Folate?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•High-dose Vitamin B6 (40mg) may cause peripheral neuropathy with symptoms like tingling or numbness in sensitive individuals; discontinue use if symptoms occur.
•Dosages of B12 (1000mcg) and 5-MTHF (500mcg) are within safe therapeutic ranges with minimal risk of adverse effects in healthy adults.
•Serine at 100mg and Riboflavin at 20mg equiv. pose low risk, with possible mild GI upset from serine but unlikely at this dose.
•Potential interactions include masking B12 deficiency if folate taken alone, but balanced here; caution with anticonvulsants, methotrexate, or B6-metabolizing drugs.
•Not recommended for pregnancy/breastfeeding without medical advice due to high B6; safe for most adults but monitor in elderly or those with kidney issues.
•Vegacaps free from common allergens like gluten, dairy, nuts; low contamination risk from reputable manufacturer.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Calcium hydrogen phosphate dihydrate
Low RiskDisodium edetate
Low RiskGellan gum
Low RiskHypromellose
Low RiskMagnesium stearate
Low RiskMicrocrystalline cellulose
Low RiskPotable water
Low RiskPotassium acetate
Low RiskWhat Are the Ingredients in Metagenics Activated B's & Folate?
Serine
100mg
Pyridoxal 5-phosphate monohydrate (Vitamin B6)
40mg
Riboflavin sodium phosphate (Riboflavin 5-phosphate sodium) (Vitamin B2)
27mg (equiv. Riboflavin 20mg)
Mecobalamin (Vitamin B12)
1000 mcg
Levomefolate calcium (5-methyltetrahydrofolate)
541 mcg (equiv. 500 mcg)
Calcium hydrogen phosphate dihydrate
Disodium edetate
Gellan gum
Hypromellose
Magnesium stearate
Microcrystalline cellulose
Potable water
Potassium acetate
Dosage & Bioavailability
How the active doses and forms in Activated B's & Folate compare to the research.
•Pyridoxal 5-phosphate monohydrate (Vitamin B6) — 40 mg a day is over the 12 mg/day upper limit (EFSA 2023); the US limit is 100 mg/day (IOM (NIH ODS)).
•2 actives have no individual amount disclosed.
•Mecobalamin (Vitamin B12) — amount not stated on the label.
Sources & References
Product
Information from www.metagenics.com
Vitamin b12
Information from www.webmd.com
Metagenics metagen methyl active technical information
Information from shop.healthmasters.com.au
Serine
Information from www.webmd.com
Drg 20065810
Information from www.mayoclinic.org
Joim.13279
Information from onlinelibrary.wiley.com
Metagen Activated B s amp Folate
Information from www.vital.ly
PMC12862861
Information from pmc.ncbi.nlm.nih.gov
25129 phosphatidylserine
Information from my.clevelandclinic.org
Products
Information from matakanapharmacy.com
STROKEAHA.122.038640
Information from www.ahajournals.org
Pyridoxine vitamin b6
Information from www.webmd.com
Products
Information from www.metagenics.com.au
Metagen activated bs folate 60 capsules
Information from www.metagenics.com.au
S12325 020 01474 z
Information from link.springer.com
What is vitamin b6 toxicity
Information from brainfoundation.org.au
Metagenics metagen methyl active 60 vegecaps
Information from mycompounding.com.au
Riboflavin
Information from www.webmd.com
Looking use l serine potential health benefits risks
Information from www.centerforcognitivehealth.com
PMC12564181
Information from pmc.ncbi.nlm.nih.gov
Products
Information from www.healthylife.com.au
Can you overdose on l methylfolate l methylfolate with vitamin b12
Information from www.droracle.ai
Riboflavin side effects.html
Information from www.drugs.com
Www.youtube.com
Information from www.youtube.com
1122
Information from www.mdpi.com
S1875213609002411
Information from www.sciencedirect.com
VitaminB6 HealthProfessional
Information from ods.od.nih.gov
911.full.pdf
Information from www.ccjm.org
Health supplements containing vitamin b6 can cause peripheral neuropathy
Information from www.tga.gov.au
Mthfr
Information from methyl-life.com
6475983
Information from academic.oup.com
L methylfolate depression
Information from www.medicalnewstoday.com
PMC12587708
Information from pmc.ncbi.nlm.nih.gov
B004GIHQVS
Information from www.amazon.com
Full
Information from www.frontiersin.org
Related
Information from www.bmj.com
Methylfolate facts
Information from methyl-life.com
Vitamin b6 is essential but too much can be toxic heres what to know to stay safe 248443
Information from theconversation.com
PMC10452085
Information from pmc.ncbi.nlm.nih.gov
Product
Information from www.metagenics.com
Risk%20assessment%20of%20%22other%20substances%22%E2%80%93%20L serine.pdf
Information from vkm.no
L methylfolate with vitamin b12 1419 0 754 3756.html
Information from www.drugs.com
473696
Information from www.tga.gov.au
The role of methylated b vitamins in lowering homocysteine and reducing heart disease risk 747fedf3bf68
Information from medium.com
Frequently Asked Questions
Common questions about Metagenics Activated B's & Folate