Natural Factors
Berberine HCl 500 mg
77/100
SUPPIE SCORE
78/100
EFFICACY
Medium
SAFETY
92/100
CLEANLINESS
What Does Berberine HCl 500 mg Do?
Natural Factors Berberine HCl 500 mg offers solid evidence for supporting blood glucose and lipid metabolism at typical study doses, though this single-capsule serving is lower than the 900-1500 mg daily totals used in most RCTs.
How does berberine support blood sugar and cholesterol levels?
What is the recommended way to take this 500 mg capsule for best results?
Are there any potential side effects or interactions with medications?
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What Are the Benefits of Berberine HCl 500 mg?
Based on proven scientific research
Blood Sugar ControlStrong
Cholesterol ManagementModerate
Metabolic HealthModerate
Cardiovascular SupportMild
Good For:
What Are the Side Effects of Natural Factors Berberine HCl 500 mg?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Common GI side effects include diarrhea, constipation, nausea, and abdominal discomfort at 500 mg doses.
•Low oral bioavailability (~1%) but sufficient for metabolic effects in studies; take with meals to reduce stomach upset.
•May lower blood pressure or blood sugar; monitor if using antihypertensive or antidiabetic medications.
•Avoid in pregnancy and breastfeeding due to potential jaundice risk in newborns.
•No major toxicity in trials up to 1500 mg/day for 3 months, but long-term data limited.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Vegetarian capsule (carbohydrate gum [cellulose], purified water)
Low RiskMicrocrystalline cellulose
Low RiskMagnesium stearate (vegetable grade)
Low RiskStearic acid
Low RiskSilica
Low RiskWhat Are the Ingredients in Natural Factors Berberine HCl 500 mg?
Berberine HCl (from Berberis vulgaris extract) (root)
500 mg
Vegetarian capsule (carbohydrate gum [cellulose], purified water)
Microcrystalline cellulose
Magnesium stearate (vegetable grade)
Stearic acid
Silica
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Dosage & Bioavailability
How the active doses and forms in Berberine HCl 500 mg compare to the research.
•Berberine HCl — 500 mg per serving; common study doses range 900-1500 mg/day split into 2-3 doses.
•Berberine HCl (from Berberis vulgaris extract) — standard hydrochloride form; low oral bioavailability around 1% due to poor absorption and first-pass metabolism.
Frequently Asked Questions
Common questions about Natural Factors Berberine HCl 500 mg