Nature Made
Vitamin D3 + K2 Softgels
82/100
SUPPIE SCORE
90/100
EFFICACY
High
SAFETY
70/100
CLEANLINESS
What Does Vitamin D3 + K2 Softgels Do?
This USP-verified supplement offers high-dose Vitamin D3 with K2 for excellent bone and immune support, backed by strong evidence. Dosages align with clinical needs for deficiency, with minimal safety concerns for healthy adults under professional guidance.
What are the benefits of combining Vitamin D3 and K2 for bone health?
Is 5000 IU of Vitamin D3 safe for daily use?
How does Vitamin K2 support cardiovascular health?
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What Are the Benefits of Vitamin D3 + K2 Softgels?
Based on proven scientific research
Bone HealthVery strong
Immune SupportStrong
Cardiovascular HealthModerate
Muscle HealthStrong
Good For:
What Are the Side Effects of Nature Made Vitamin D3 + K2 Softgels?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•Vitamin D3 at 5000 IU is generally safe for adults with deficiency but may cause hypercalcemia if levels exceed 150 ng/mL; monitor serum levels with long-term use.
•Vitamin K2 (MK-7) 100 mcg is well-tolerated with no significant side effects reported in studies; safe for most adults.
•Potential interactions include Vitamin K2 with anticoagulants like warfarin, requiring dosage adjustments; Vitamin D3 may interact with thiazide diuretics or digoxin, increasing hypercalcemia risk.
•Not recommended for pregnant or breastfeeding women without medical advice; 5000 IU Vitamin D3 exceeds typical needs but is safe up to 4000 IU daily per guidelines.
•Soy and corn oils may pose allergy risks; carmine color from insects could affect vegans or those with sensitivities.
•USP verification ensures quality and purity, minimizing contamination risks.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Low Risk
Low Risk
Low Risk
Low Risk
Low Risk
What Are the Ingredients in Nature Made Vitamin D3 + K2 Softgels?
Vitamin D3 (as Cholecalciferol)
125 mcg (5000 IU)
Vitamin K2 (as all-trans Menaquinone-7)
100 mcg
Soybean Oil
Gelatin
Glycerin
Corn Oil
Colors Added (Including Carmine)
Sources & References
PMC9996107
Information from pmc.ncbi.nlm.nih.gov
PMC7238900
Information from pmc.ncbi.nlm.nih.gov
PMC5748731
Information from pmc.ncbi.nlm.nih.gov
PMC4539891
Information from pmc.ncbi.nlm.nih.gov
K2 d3 with losartan 4439 20290 1489 0.html
Information from www.drugs.com
PMC12691719
Information from pmc.ncbi.nlm.nih.gov
K2 plus d3 with vitamin d3 1661 19036 646 5790.html
Information from www.drugs.com
PMC3022248
Information from pmc.ncbi.nlm.nih.gov
PMC11676630
Information from pmc.ncbi.nlm.nih.gov
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Products
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PMC5949172
Information from pmc.ncbi.nlm.nih.gov
Cholecalciferol,vitamin d3.html
Information from www.drugs.com
Products
Information from www.cub.com
PMC5494092
Information from pmc.ncbi.nlm.nih.gov
PMC7406600
Information from pmc.ncbi.nlm.nih.gov
K2 d3 with spironolactone 4439 20290 2105 0.html
Information from www.drugs.com
PMC10351276
Information from pmc.ncbi.nlm.nih.gov
Menaquinone,vitamin k2.html
Information from www.drugs.com
PMC506781
Information from pmc.ncbi.nlm.nih.gov
Vitamin d3 k2 softgels
Information from www.naturemade.com
PMC7230802
Information from pmc.ncbi.nlm.nih.gov
PMC7999920
Information from pmc.ncbi.nlm.nih.gov
PMC8596038
Information from pmc.ncbi.nlm.nih.gov
3659087
Information from shop.lowesfoods.com
PMC8774117
Information from pmc.ncbi.nlm.nih.gov
Products
Information from www.naturemade.com
K2 d3 with multivitamin 4439 20290 1661 0.html
Information from www.drugs.com
Cholecalciferol menaquinone,k2 d3.html
Information from www.drugs.com
0003160404345
Information from www.foodsco.net
Collections
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Nature made vitamin d3 k2 gummies vitamin d 5000 iu per serving bone immune support 50 ct prodid 502218
Information from www.cvs.com
Cholecalciferol menaquinone,k2 d3.html
Information from www.drugs.com
PMC8121044
Information from pmc.ncbi.nlm.nih.gov
PMC8483258
Information from pmc.ncbi.nlm.nih.gov
Drug interactions
Information from www.drugs.com
ID=300425544 product
Information from www.walgreens.com
B09SR2KX9D
Information from www.amazon.com
PMC9237441
Information from pmc.ncbi.nlm.nih.gov
Multivitamin,k2 plus d3.html
Information from www.drugs.com
PMC9011124
Information from pmc.ncbi.nlm.nih.gov
Products
Information from www.naturemade.com
Products
Information from www.naturemade.com
B0D96MYSJJ
Information from www.amazon.com
NBK500914
Information from www.ncbi.nlm.nih.gov
2528494214
Information from www.walmart.com
PMC7436967
Information from pmc.ncbi.nlm.nih.gov
PMC4821095
Information from pmc.ncbi.nlm.nih.gov
146550424397
Information from www.ebay.com
PMC5613455
Information from pmc.ncbi.nlm.nih.gov
PMC9099759
Information from pmc.ncbi.nlm.nih.gov
Frequently Asked Questions
Common questions about Nature Made Vitamin D3 + K2 Softgels