Nature's Plus
Berberine 500 mg
74/100
SUPPIE SCORE
65/100
EFFICACY
Medium
SAFETY
94/100
CLEANLINESS
What Does Berberine 500 mg Do?
Nature's Plus Berberine 500 mg supplies a standard 500 mg dose of berberine from Berberis aristata root per serving, consistent with amounts used in many metabolic studies, though product potency can vary and actual content may be lower than labeled.
What is the recommended daily serving and timing for this berberine supplement?
How does the bioavailability of standard berberine compare to enhanced forms like dihydroberberine?
Are there any specific populations that should avoid berberine supplements?
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What Are the Benefits of Berberine 500 mg?
Based on proven scientific research
Blood sugar regulationModerate
Lipid metabolismModerate
Gut health supportMild
Good For:
What Are the Side Effects of Nature's Plus Berberine 500 mg?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Berberine (500 mg per serving) commonly causes mild GI upset such as diarrhea, constipation, or nausea at typical doses.
•May interact with CYP3A4 or CYP2D6 substrates; consult physician if taking prescription medications like metformin or statins.
•Short half-life requires divided dosing (e.g., 2–3 times daily) to maintain levels.
•Not recommended during pregnancy or breastfeeding due to limited safety data.
•Variability in actual berberine content across commercial products reported in analyses.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Vegetable cellulose
Low RiskMicrocrystalline cellulose
Low RiskStearic acid
Low RiskWhat Are the Ingredients in Nature's Plus Berberine 500 mg?
Berberine (from Berberis aristata root)
500 mg
vegetable cellulose
microcrystalline cellulose
stearic acid
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Dosage & Bioavailability
How the active doses and forms in Berberine 500 mg compare to the research.
•Berberine (from Berberis aristata root) is listed at 500 mg per serving; without a source-specific reference range, dose adequacy cannot be graded.
•Berberine (from Berberis aristata root) specifies the Berberis aristata root form; any bioavailability comparison must use evidence for that exact form.
Sources & References
Berberine 500 mg
Information from www.naturesplus.com
Products
Information from naturestruth.com
Natures plus pro berberine 1500mg 8000829
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PMC5807210
Information from pmc.ncbi.nlm.nih.gov
Frequently Asked Questions
Common questions about Nature's Plus Berberine 500 mg