NOW Foods
NOW Supplements, TMG Betaine (Trimethylglycine) 1,000 mg, Liver Support*, 100 Tablets
85/100
SUPPIE SCORE
78/100
EFFICACY
High
SAFETY
86/100
CLEANLINESS
What Does NOW Supplements, TMG Betaine (Trimethylglycine) 1,000 mg, Liver Support*, 100 Tablets Do?
Provides 1,000 mg trimethylglycine per tablet to reliably reduce blood homocysteine levels, though clinical liver outcomes lack robust trial support.
How does TMG differ from Betaine HCl?
Can taking TMG raise my LDL cholesterol levels?
Should I take this supplement with meals or on an empty stomach?
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What Are the Benefits of NOW Supplements, TMG Betaine (Trimethylglycine) 1,000 mg, Liver Support*, 100 Tablets?
Based on proven scientific research
Homocysteine ReductionVery strong
Muscular Endurance and Work CapacityModerate
Hepatic Methylation SupportMild
Good For:
What Are the Side Effects of NOW Foods NOW Supplements, TMG Betaine (Trimethylglycine) 1,000 mg, Liver Support*, 100 Tablets?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•Doses of betaine anhydrous exceeding 3,000 to 4,000 mg per day have been shown in multiple clinical trials to cause modest, dose-dependent increases in total and LDL cholesterol.
•Mild gastrointestinal distress, including nausea, stomach cramps, bloating, and diarrhea, is the most common side effect, especially when initiating therapy or taking 3 or more tablets at once.
•Individuals with cystathionine beta-synthase (CBS) deficiency should use betaine only under medical supervision due to a demonstrated risk of severe hypermethioninemia and secondary cerebral edema.
•Safety during pregnancy and breastfeeding has not been established in clinical studies, so avoid use unless directed by an obstetric healthcare provider.
•The tablets are highly hygroscopic; keep the desiccant packet inside and ensure the container remains tightly sealed to prevent moisture-induced degradation.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Microcrystalline cellulose
Low RiskHydroxypropyl cellulose
Low RiskVegetarian coating
Low RiskStearic acid (vegetable source)
Low RiskCroscarmellose sodium
Low RiskMagnesium stearate (vegetable source)
Low RiskWhat Are the Ingredients in NOW Foods NOW Supplements, TMG Betaine (Trimethylglycine) 1,000 mg, Liver Support*, 100 Tablets?
Trimethylglycine (TMG) (Betaine Anhydrous)
1000 mg
Microcrystalline Cellulose
Hydroxypropyl Cellulose
Vegetarian Coating
Stearic Acid (vegetable source)
Croscarmellose Sodium
Magnesium Stearate (vegetable source)
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Dosage & Bioavailability
How the active doses and forms in NOW Supplements, TMG Betaine (Trimethylglycine) 1,000 mg, Liver Support*, 100 Tablets compare to the research.
•Trimethylglycine (TMG) (Betaine Anhydrous) — 2-6 g a day; studies use 2.5-6 g/day. The higher daily dose reaches it; the lowest falls short.
•Trimethylglycine (TMG) (Betaine Anhydrous) — trimethylglycine is one of the better-absorbed, well-studied forms of betaine (tmg).
Frequently Asked Questions
Common questions about NOW Foods NOW Supplements, TMG Betaine (Trimethylglycine) 1,000 mg, Liver Support*, 100 Tablets