Pure Encapsulations
B-Complex Plus
64/100
SUPPIE SCORE
82/100
EFFICACY
Low
SAFETY
96/100
CLEANLINESS
What Does B-Complex Plus Do?
8 actives: 7 vitamins and minerals and 1 other (niacin). Of 8 actives with a studied range, 5 are at or above studied amounts and 1 more covers the daily reference intake. 2 actives are over their upper limits.
Is this B-complex suitable if I already take a multivitamin?
Could the high vitamin B12 or niacin dose cause side effects for me?
Is this a good option for low energy if I do not have a confirmed deficiency?
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What Are the Benefits of B-Complex Plus?
Based on proven scientific research
B vitamin repletionVery strong
Energy metabolismStrong
Nervous system supportStrong
Methylation supportStrong
Red blood cell supportModerate
Good For:
What Are the Side Effects of Pure Encapsulations B-Complex Plus?
Always consult your health practitioner if in doubt.
RiskHigh Risk
Overview
•Vitamin B3: 108 mg per serving is over the 35 mg/day upper limit (IOM (NIH ODS)) (about 3.1 times the limit). Nicotinic acid above this limit causes flushing, and high doses taken for a long time can harm the liver. Suppie lowered this product's safety rating by one level for this reason.
•Vitamin B6: 16.7 mg per serving is above the 12 mg/day EU upper limit (EFSA 2023), though within the US limit of 100 mg/day. Taking more than this for months is linked to nerve damage (peripheral neuropathy: numbness, tingling or pain in hands and feet), which usually improves after stopping.
•Generally well tolerated when taken as directed, but the high-dose B vitamin profile can cause nausea, headache, bright yellow urine, or niacin-related flushing in sensitive users.
•Vitamin B6 is moderate-dose at 16.7 mg; avoid stacking with other high-B6 supplements long term because excessive cumulative B6 intake may contribute to neuropathy.
•Use medical guidance if taking levodopa without carbidopa, anticonvulsants, methotrexate, certain antibiotics, diabetes medications, or if you use metformin or acid-suppressing drugs and are monitoring B12 status.
•During pregnancy or breastfeeding, use only with clinician guidance because it is not a complete prenatal and contains high-potency B vitamins.
•Certified gluten-free and vegan-friendly according to the source; no major food allergens are declared, but sensitive users should verify the current bottle label.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Vegetarian capsule (cellulose, water)
Low RiskCellulose
Low RiskWater
Low RiskAscorbyl palmitate
GoodWhat Are the Ingredients in Pure Encapsulations B-Complex Plus?
Thiamin
100 mg
Riboflavin
12.7 mg
Niacin
108 mg NE
Vitamin B6
16.7 mg
Folate
667 mcg DFE
Vitamin B12
400 mcg
Biotin
400 mcg
Pantothenic acid
100 mg
vegetarian capsule (cellulose, water)
cellulose
water
ascorbyl palmitate
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Dosage & Bioavailability
How the active doses and forms in B-Complex Plus compare to the research.
•Vitamin B12 is very high at 400 mcg, useful for repletion but far above daily requirements.
•Folate is provided at 667 mcg DFE, and the source identifies 5-MTHF as an active folate form.
•B6 is 16.7 mg, so avoid stacking with other high-dose B6 products.
Frequently Asked Questions
Common questions about Pure Encapsulations B-Complex Plus