Pure Encapsulations
B-Complex Plus with Metafolin L-5-MTHF
94/100
SUPPIE SCORE
95/100
EFFICACY
High
SAFETY
96/100
CLEANLINESS
What Does B-Complex Plus with Metafolin L-5-MTHF Do?
This high-potency B-complex offers excellent efficacy with activated, bioavailable forms supporting energy, stress, and methylation at optimal doses. Dosages are effective and safe, with hypoallergenic, clean formulation minimizing risks for most adults.
What are the benefits of activated forms like L-5-MTHF and methylcobalamin in this B-complex?
How does this supplement support energy metabolism and stress response?
Is this B-complex suitable for individuals with MTHFR gene mutations?
Chat with Suppie
What Are the Benefits of B-Complex Plus with Metafolin L-5-MTHF?
Based on proven scientific research
Energy productionVery strong
Nervous system supportVery strong
Stress reductionStrong
Methylation supportVery strong
Good For:
What Are the Side Effects of Pure Encapsulations B-Complex Plus with Metafolin L-5-MTHF?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•All B-vitamins in this formulation are water-soluble with low toxicity risk at stated doses, well below upper limits (e.g., B6 at 16.7 mg vs. 100 mg UL).
•Activated forms like Metafolin L-5-MTHF and methylcobalamin reduce risks for those with MTHFR polymorphisms, but monitor for mild GI upset in sensitive users.
•Minimal drug interactions; however, high B6 may enhance levodopa effects, and B12 could interfere with metformin absorption—consult physician if on medications.
•Safe for most adults including elderly; not recommended for children under 18 without medical advice; limited data for pregnancy/lactation, use with caution.
•Hypoallergenic formula free of common allergens, gluten, and GMOs; vegetarian capsules pose no gelatin-related risks.
•Long-term use supports B-vitamin needs but periodic blood tests advised to avoid masking deficiencies or excess in rare cases.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Cellulose
Low RiskWater
Low RiskWhat Are the Ingredients in Pure Encapsulations B-Complex Plus with Metafolin L-5-MTHF?
Thiamin (as thiamin HCl) (B1)
100 mg
Riboflavin (as vitamin B2 and 60% riboflavin 5' phosphate (activated B2))
12.7 mg
Niacin (as niacinamide and 80% inositol hexaniacinate (no flush niacin))
108 mg
Vitamin B6 (as pyridoxine HCl and 40% pyridoxal 5' phosphate (activated B6))
16.7 mg
Folate (as Metafolin, L-5-MTHF) (400 mcg L-5-MTHF)
667 mcg DFE
Vitamin B12 (as methylcobalamin)
400 mcg
Biotin
400 mcg
Pantothenic acid (as calcium pantothenate) (B5)
100 mg
Cellulose
Water
Scan the bottle in your cupboard
Same graded report you just read — on any label, in about 10 seconds.
Dosage & Bioavailability
How the active doses and forms in B-Complex Plus with Metafolin L-5-MTHF compare to the research.
•Thiamin (as thiamin HCl) (B1) — 100 mg per serving; within the 5-500 mg/day typically used in studies. This range is provisional until reviewed.
•1 of 8 actives with a studied range are below it.
•Niacin (as niacinamide and 80% inositol hexaniacinate (no flush niacin)) — 108 mg per serving is over the 35 mg/day upper limit (IOM (NIH ODS)).
Sources & References
Frequently Asked Questions
Common questions about Pure Encapsulations B-Complex Plus with Metafolin L-5-MTHF