Pure Encapsulations
B12 Folate (Metafolin®)
92/100
SUPPIE SCORE
85/100
EFFICACY
High
SAFETY
98/100
CLEANLINESS
What Does B12 Folate (Metafolin®) Do?
This Pure Encapsulations B12 Folate pairs 800 mcg Metafolin® (L-5-MTHF) with 800 mcg methylcobalamin for direct bioactive support of methylation, homocysteine balance, and energy pathways without conversion steps required by standard forms.
What is the difference between Metafolin® and regular folic acid?
Who might benefit most from taking this methylated B12 and folate combination?
How should this supplement be taken for best absorption?
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What Are the Benefits of B12 Folate (Metafolin®)?
Based on proven scientific research
Homocysteine MetabolismStrong
Energy ProductionModerate
Neurological HealthStrong
Red Blood Cell FormationModerate
Good For:
What Are the Side Effects of Pure Encapsulations B12 Folate (Metafolin®)?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•Metafolin® (L-5-MTHF) and methylcobalamin are bioactive forms with excellent bioavailability and low toxicity risk at 800 mcg doses.
•No significant adverse effects reported in studies at these levels; suitable for most adults including those with MTHFR polymorphisms.
•Vitamin B12 has no established upper limit due to high safety margin; excess is typically excreted.
•Gluten-free and hypoallergenic formulation minimizes common allergen exposure.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Hypoallergenic plant cellulose
Low RiskVegetarian capsule (hypromellose, water)
Low RiskAscorbyl palmitate
GoodWhat Are the Ingredients in Pure Encapsulations B12 Folate (Metafolin®)?
Folate (calcium L-5-methyltetrahydrofolate, Metafolin®)
800 mcg
Vitamin B12 (methylcobalamin)
800 mcg
Hypoallergenic plant cellulose
Vegetarian capsule (hypromellose, water)
Ascorbyl palmitate
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Dosage & Bioavailability
How the active doses and forms in B12 Folate (Metafolin®) compare to the research.
•Folate (as calcium L-5-methyltetrahydrofolate, Metafolin®) — 800 mcg per capsule; provides 1,333 mcg DFE, matching or exceeding typical supplemental ranges of 400-800 mcg L-5-MTHF.
•Vitamin B12 (as methylcobalamin) — 800 mcg per capsule; active coenzyme form with high bioavailability compared to cyanocobalamin.
Frequently Asked Questions
Common questions about Pure Encapsulations B12 Folate (Metafolin®)