Pure Encapsulations
Folate 400
94/100
SUPPIE SCORE
92/100
EFFICACY
High
SAFETY
98/100
CLEANLINESS
What Does Folate 400 Do?
Pure Encapsulations Folate 400 provides bioavailable 400 mcg L-5-MTHF, aligning with effective doses for methylation support and MTHFR issues. Hypoallergenic and free of common allergens, it's exceptionally safe with strong evidence for cardiovascular and neural benefits.
What are the benefits of L-5-MTHF over synthetic folic acid?
How does this supplement support cardiovascular health?
Is this folate form suitable for individuals with MTHFR mutations?
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What Are the Benefits of Folate 400?
Based on proven scientific research
Cardiovascular HealthStrong
Neural HealthStrong
Cellular HealthModerate
Good For:
What Are the Side Effects of Pure Encapsulations Folate 400?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•Folate 400 mcg is well within safe daily limits (UL 1,000 mcg for adults), minimizing overdose risk.
•Generally safe for pregnancy at this dose, but consult physician for folate needs during gestation.
•Low interaction potential; may enhance efficacy of antidepressants but monitor with anticonvulsants.
•Hypoallergenic formulation reduces sensitivity risks; suitable for most adults including elderly.
•No known contaminants from reputable brand; long-term use supports methylation without accumulation issues.
•Avoid in untreated B12 deficiency to prevent masking pernicious anemia.
Potential Side Effects
Negative Interactions
Allergens
None declared
Inactive Ingredients
Hypoallergenic plant fiber (cellulose)
Low RiskAscorbyl palmitate
GoodWhat Are the Ingredients in Pure Encapsulations Folate 400?
Metafolin L-5-MTHF (L-5-methyltetrahydrofolate, glucosamine salt)
400 mcg (240 mcg L-5-MTHF)
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Dosage & Bioavailability
How the active doses and forms in Folate 400 compare to the research.
•Metafolin L-5-MTHF (L-5-methyltetrahydrofolate, glucosamine salt) — 400 mcg per serving; within the 400 mcg/day typically used in studies. This range is provisional until reviewed.
Sources & References
Frequently Asked Questions
Common questions about Pure Encapsulations Folate 400