Sports Research
Advanced B-Complex Methylated Folate & B12
71/100
SUPPIE SCORE
68/100
EFFICACY
Medium
SAFETY
86/100
CLEANLINESS
What Does Advanced B-Complex Methylated Folate & B12 Do?
This methylated B-complex delivers bioactive forms of folate (as L-5-MTHF calcium salt), B12 (methylcobalamin), B6 (P5P), and other B vitamins plus choline and inositol at levels that reliably support homocysteine metabolism and energy pathways in people.
Who is most likely to benefit from the methylated forms of folate and B12 in this complex?
How does the inclusion of choline and inositol enhance the formula compared to standard B-complexes?
Are there any long-term safety considerations with the high biotin and niacinamide levels when taken daily?
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What Are the Benefits of Advanced B-Complex Methylated Folate & B12?
Based on proven scientific research
Homocysteine ReductionStrong
Energy MetabolismModerate
Methylation SupportModerate
Neurological HealthMild
Cardiovascular Risk FactorsMild
Good For:
What Are the Side Effects of Sports Research Advanced B-Complex Methylated Folate & B12?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•Niacin: 80 mg a day is over the 35 mg/day upper limit (ods.od.nih.gov) (about 2.3 times the limit). Suppie lowered this product's safety rating by one level for this reason.
•Provides bioactive methylated folate (680 mcg DFE) and methylcobalamin that support homocysteine remethylation without masking B12 deficiency when both are supplied together.
•Niacinamide at 80 mg and B6 (P5P) at 8.5 mg are well below EFSA/NAM upper limits (900 mg and 12-100 mg respectively) with low risk of flushing or neuropathy in typical use.
•Choline (25 mg as bitartrate) and inositol (100 mg) doses are conservative and align with safe supplemental ranges for methylation support.
•Suitable for most adults including vegans; consult a healthcare provider before use in pregnancy, if taking medications that affect folate metabolism, or with known B12 absorption issues.
•No major allergens from actives; other ingredients include coconut MCT and sunflower lecithin but no common top allergens like soy, gluten, or dairy in the formula core.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Non-gmo modified tapioca starch
Low RiskVegetable glycerin
Low RiskPurified water
Low RiskAnnatto
Low RiskLycopene
GoodCoconut
GoodMct oil
Low RiskSunflower lecithin
Low RiskRice bran wax
Low RiskWhat Are the Ingredients in Sports Research Advanced B-Complex Methylated Folate & B12?
Vitamin B1 (as thiamine HCl)
6 mg
Riboflavin (as riboflavin 5'-phosphate sodium)
6.5 mg
Niacin (as niacinamide)
80 mg
Vitamin B6 (as pyridoxal 5'-phosphate)
8.5 mg
Folate (as L-5-methyltetrahydrofolic acid, calcium salt)
680 mcg DFE
Vitamin B12 (as methylcobalamin)
12 mcg
Biotin
300 mcg
Pantothenic Acid (as D-calcium pantothenate)
25 mg
Choline (as choline bitartrate)
25 mg
Inositol
100 mg
non-GMO modified tapioca starch
vegetable glycerin
purified water
annatto
lycopene
coconut
MCT oil
sunflower lecithin
rice bran wax
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Dosage & Bioavailability
How the active doses and forms in Advanced B-Complex Methylated Folate & B12 compare to the research.
•Folate (as L-5-methyltetrahydrofolic acid, calcium salt) — 680 mcg a day; within the 400-1,360 mcg/day typically used in studies. This range is provisional until reviewed.
•Niacin (as niacinamide) — 80 mg a day is over the 35 mg/day upper limit (ods.od.nih.gov).
Frequently Asked Questions
Common questions about Sports Research Advanced B-Complex Methylated Folate & B12