Thorne
5-MTHF 1 mg Methylfolate
91/100
SUPPIE SCORE
92/100
EFFICACY
High
SAFETY
90/100
CLEANLINESS
What Does 5-MTHF 1 mg Methylfolate Do?
Thorne's 5-MTHF 1 mg offers excellent efficacy as bioactive methylfolate for methylation support, cardiovascular health, and fetal development, with optimal dosage for MTHFR variants. Highly safe for adults, including pregnancy, with no notable concerns or allergens.
What is the role of methylfolate in supporting methylation for individuals with MTHFR mutations?
How does 5-MTHF compare to folic acid in terms of bioavailability and efficacy for mood support?
Is this dosage of 5-MTHF suitable for pregnant women to prevent neural tube defects?
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What Are the Benefits of 5-MTHF 1 mg Methylfolate?
Based on proven scientific research
Methylation SupportVery strong
Cardiovascular HealthStrong
Mood RegulationModerate
Fetal DevelopmentVery strong
Good For:
What Are the Side Effects of Thorne 5-MTHF 1 mg Methylfolate?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•The 1.7 mg DFE dosage of L-5-MTHF is well within safe limits (UL 1000 mcg DFE for adults), supported by toxicity studies showing no adverse effects up to 400 mg/kg/day in rats.
•Generally well-tolerated with minimal side effects; contraindicated in hypersensitivity to ingredients like cellulose derivatives.
•May interfere with methotrexate's anti-neoplastic activity in cancer therapy but safe for anti-inflammatory use in psoriasis or rheumatoid arthritis.
•Suitable for pregnancy after consulting a healthcare provider; recommended at 1 mg for fetal development support without unmetabolized folic acid risks.
•No allergens present; free from common triggers like gluten, dairy, soy, and nuts, making it low-risk for sensitivities.
•Long-term use safe at this dose, with studies showing efficacy and tolerability up to 24 weeks at similar or higher levels without significant interactions.
Potential Side Effects
Negative Interactions
Inactive Ingredients
Microcrystalline cellulose
Low RiskHypromellose (derived from cellulose)
Low RiskLeucine
Low RiskSilicon dioxide
Low RiskWhat Are the Ingredients in Thorne 5-MTHF 1 mg Methylfolate?
Folate (as L-5-Methyltetrahydrofolate)
1.7 mg DFE
Microcrystalline Cellulose
Hypromellose (derived from cellulose)
Leucine
Silicon Dioxide
Dosage & Bioavailability
How the active doses and forms in 5-MTHF 1 mg Methylfolate compare to the research.
•Folate (as L-5-Methyltetrahydrofolate) — 1,700 mcg per serving is over the 1,000 mcg/day upper limit (IOM (NIH ODS)).
Sources & References
PMC9380836
Information from pmc.ncbi.nlm.nih.gov
Dp
Information from www.thorne.com
Folate HealthProfessional
Information from ods.od.nih.gov
NBK554487
Information from www.ncbi.nlm.nih.gov
Store.mayoclinic.com
Information from store.mayoclinic.com
5 mthf 1 mg
Information from www.thorne.com
Dp
Information from www.thorne.com
35392283
Information from pubmed.ncbi.nlm.nih.gov
PMC8961567
Information from pmc.ncbi.nlm.nih.gov
PMC10685998
Information from pmc.ncbi.nlm.nih.gov
19909688
Information from pubmed.ncbi.nlm.nih.gov
B00FY8IQ7C
Information from www.amazon.com
Dp
Information from www.thorne.com
126047541
Information from www.walmart.com
B005BSMVFS
Information from www.amazon.com
Dp
Information from www.thorne.com
PMC11435031
Information from pmc.ncbi.nlm.nih.gov
Dp
Information from www.thorne.com
PMC6816227
Information from pmc.ncbi.nlm.nih.gov
Dp
Information from www.thorne.com
Dp
Information from www.thorne.com
Dp
Information from www.thorne.com
PMC6699731
Information from pmc.ncbi.nlm.nih.gov
Frequently Asked Questions
Common questions about Thorne 5-MTHF 1 mg Methylfolate