Thorne - 5-MTHF 1 mg Methylfolate

Suppie Report

Thorne

5-MTHF 1 mg Methylfolate

A grade
91/100
SUPPIE SCORE
92/100
EFFICACY
High
SAFETY
90/100
CLEANLINESS

What Does 5-MTHF 1 mg Methylfolate Do?

Thorne's 5-MTHF 1 mg offers excellent efficacy as bioactive methylfolate for methylation support, cardiovascular health, and fetal development, with optimal dosage for MTHFR variants. Highly safe for adults, including pregnancy, with no notable concerns or allergens.
What is the role of methylfolate in supporting methylation for individuals with MTHFR mutations?
How does 5-MTHF compare to folic acid in terms of bioavailability and efficacy for mood support?
Is this dosage of 5-MTHF suitable for pregnant women to prevent neural tube defects?
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What Are the Benefits of 5-MTHF 1 mg Methylfolate?

Based on proven scientific research

Methylation SupportVery strong
Cardiovascular HealthStrong
Mood RegulationModerate
Fetal DevelopmentVery strong

Good For:

What Are the Side Effects of Thorne 5-MTHF 1 mg Methylfolate?

Always consult your health practitioner if in doubt.

RiskLow Risk

Overview

•The 1.7 mg DFE dosage of L-5-MTHF is well within safe limits (UL 1000 mcg DFE for adults), supported by toxicity studies showing no adverse effects up to 400 mg/kg/day in rats.
•Generally well-tolerated with minimal side effects; contraindicated in hypersensitivity to ingredients like cellulose derivatives.
•May interfere with methotrexate's anti-neoplastic activity in cancer therapy but safe for anti-inflammatory use in psoriasis or rheumatoid arthritis.
•Suitable for pregnancy after consulting a healthcare provider; recommended at 1 mg for fetal development support without unmetabolized folic acid risks.
•No allergens present; free from common triggers like gluten, dairy, soy, and nuts, making it low-risk for sensitivities.
•Long-term use safe at this dose, with studies showing efficacy and tolerability up to 24 weeks at similar or higher levels without significant interactions.

Potential Side Effects

Negative Interactions

Inactive Ingredients

Microcrystalline cellulose
Low Risk
Hypromellose (derived from cellulose)
Low Risk
Leucine
Low Risk
Silicon dioxide
Low Risk

What Are the Ingredients in Thorne 5-MTHF 1 mg Methylfolate?

Folate (as L-5-Methyltetrahydrofolate)
1.7 mg DFE
Microcrystalline Cellulose
Hypromellose (derived from cellulose)
Leucine
Silicon Dioxide

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Dosage & Bioavailability

How the active doses and forms in 5-MTHF 1 mg Methylfolate compare to the research.

•Folate (as L-5-Methyltetrahydrofolate) — 1,700 mcg per serving is over the 1,000 mcg/day upper limit (IOM (NIH ODS)).

Frequently Asked Questions

Common questions about Thorne 5-MTHF 1 mg Methylfolate