Thorne
B-Complex #12
91/100
SUPPIE SCORE
92/100
EFFICACY
High
SAFETY
92/100
CLEANLINESS
What Does B-Complex #12 Do?
Thorne B-Complex #12 offers excellent efficacy with active, bioavailable B vitamins at optimal dosages for energy, nerve health, and methylation support. High-quality formulation ensures safety with minimal risks for healthy adults, though consult for medication interactions.
What are the benefits of active B vitamins like methylcobalamin and L-5-MTHF in this formula?
How does the high Vitamin B12 dosage support energy and nerve health?
Is this B-complex suitable for vegetarians or those with MTHFR mutations?
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What Are the Benefits of B-Complex #12?
Based on proven scientific research
Energy ProductionVery strong
Nervous System SupportVery strong
Red Blood Cell FormationStrong
Mood RegulationStrong
Good For:
What Are the Side Effects of Thorne B-Complex #12?
Always consult your health practitioner if in doubt.
RiskLow Risk
Overview
•All B vitamins in this formulation are at dosages well within safe upper limits (e.g., B12 at 600 mcg vs. no established UL), supported by NIH guidelines for healthy adults.
•Active forms like methylcobalamin and L-5-MTHF enhance bioavailability with low risk of side effects; suitable for those with MTHFR polymorphisms per Examine.com research.
•Potential mild GI upset from high B-vitamin doses in sensitive individuals, but Thorne's quality manufacturing minimizes contamination risks as per third-party testing.
•No major drug interactions for this formula, though high niacin may enhance blood pressure meds; consult physician if on anticonvulsants or metformin (PubMed studies).
•Safe for pregnancy at recommended doses (folate 667 mcg DFE aligns with RDA), but not for children under 18 without medical advice; low allergen profile with no gluten, dairy, or soy.
•Long-term use is generally safe due to water-soluble nature of B vitamins, with excess excreted; monitor for rare hypersensitivity to capsule materials.
Potential Side Effects
Negative Interactions
Allergens
None declared (gluten-free, dairy-free, soy-free)
Inactive Ingredients
Hypromellose (derived from cellulose) capsule
Low RiskCalcium laurate
Low RiskMagnesium citrate
Low RiskSilicon dioxide
Low RiskWhat Are the Ingredients in Thorne B-Complex #12?
Thiamine (as Thiamine HCl)
40 mg
Riboflavin (25 mg as Riboflavin and 5 mg as Riboflavin 5'-Phosphate Sodium)
30 mg
Niacin (as Niacinamide)
80 mg
Vitamin B6 (25 mg as Pyridoxal 5'-Phosphate and 5 mg as Pyridoxine HCl)
30 mg
Folate (400 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
667 mcg DFE
Vitamin B12 (600 mcg as Methylcobalamin)
600 mcg
Biotin
80 mcg
Pantothenic Acid (as Calcium Pantothenate)
45 mg
Choline (as Choline Citrate)
14 mg
Hypromellose (derived from cellulose) capsule
Calcium Laurate
Magnesium Citrate
Silicon Dioxide
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Dosage & Bioavailability
How the active doses and forms in B-Complex #12 compare to the research.
•Thiamine (as Thiamine HCl) — 40 mg per serving; within the 5-500 mg/day typically used in studies. This range is provisional until reviewed.
•Niacin (as Niacinamide) — 80 mg per serving is over the 35 mg/day upper limit (IOM (NIH ODS)).
•Vitamin B6 (25 mg as Pyridoxal 5'-Phosphate and 5 mg as Pyridoxine HCl) — 30 mg per serving is over the 12 mg/day upper limit (EFSA 2023); the US limit is 100 mg/day (IOM (NIH ODS)).
Sources & References
Frequently Asked Questions
Common questions about Thorne B-Complex #12