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THORNE® - Methyl-Guard®

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THORNE®

Methyl-Guard®

B grade
75/100
SUPPIE SCORE
92/100
EFFICACY
Medium
SAFETY
76/100
CLEANLINESS

What Does Methyl-Guard® Do?

Excellent high-dose active B-vitamins and betaine optimize homocysteine reduction and methylation. Strong evidence for cardiovascular benefits. Medium safety due to high B6 neuropathy risk with prolonged use.
How does Methyl-Guard support homocysteine metabolism?
What are the benefits of active forms like P5P and methylfolate?
Is 1.8g betaine daily safe for long-term use?
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What Are the Benefits of Methyl-Guard®?

Based on proven scientific research

Homocysteine ReductionVery strong
Methylation SupportVery strong
Cardiovascular HealthStrong
Cognitive FunctionModerate

Good For:

What Are the Side Effects of THORNE® Methyl-Guard®?

Always consult your health practitioner if in doubt.

RiskMedium Risk

Overview

High B6 (20.4mg) dose may cause peripheral neuropathy with long-term use exceeding 3-6 months.
B12 (1.2mg) and folate safe at these levels; active forms enhance bioavailability.
Betaine 1.8g well-tolerated but may cause mild GI upset in sensitive individuals.
Contraindicated with methotrexate cancer therapy due to 5-MTHF interference.
Gluten-, dairy-, soy-free; suitable for most allergens but contains glucosamine salt.
Consult physician if pregnant; high B-vitamins generally safe during pregnancy.

Potential Side Effects

Negative Interactions

Inactive Ingredients

Hypromellose (derived from cellulose)
Low Risk
Silicon dioxide
Low Risk
Calcium citrate
Low Risk
Calcium laurate
Low Risk

What Are the Ingredients in THORNE® Methyl-Guard®?

Vitamin B6 (as Pyridoxal 5'-Phosphate)
20.4 mg
Folate (1.2 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
2 mg DFE
Vitamin B12 (as Methylcobalamin)
1.2 mg
Betaine Anhydrous (Trimethylglycine)
1.8 g
Hypromellose (derived from cellulose)
Silicon Dioxide
Calcium Citrate
Calcium Laurate

Frequently Asked Questions

Common questions about THORNE® Methyl-Guard®