THORNE®
Methyl-Guard®
80/100
SUPPIE SCORE
92/100
EFFICACY
Medium
SAFETY
90/100
CLEANLINESS
What Does Methyl-Guard® Do?
Excellent high-dose active B-vitamins and betaine optimize homocysteine reduction and methylation. Strong evidence for cardiovascular benefits. Medium safety due to high B6 neuropathy risk with prolonged use.
How does Methyl-Guard support homocysteine metabolism?
What are the benefits of active forms like P5P and methylfolate?
Is 1.8g betaine daily safe for long-term use?
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What Are the Benefits of Methyl-Guard®?
Based on proven scientific research
Homocysteine ReductionVery strong
Methylation SupportVery strong
Cardiovascular HealthStrong
Cognitive FunctionModerate
Good For:
What Are the Side Effects of THORNE® Methyl-Guard®?
Always consult your health practitioner if in doubt.
RiskMedium Risk
Overview
•High B6 (20.4mg) dose may cause peripheral neuropathy with long-term use exceeding 3-6 months.
•B12 (1.2mg) and folate safe at these levels; active forms enhance bioavailability.
•Betaine 1.8g well-tolerated but may cause mild GI upset in sensitive individuals.
•Contraindicated with methotrexate cancer therapy due to 5-MTHF interference.
•Gluten-, dairy-, soy-free; suitable for most allergens but contains glucosamine salt.
•Consult physician if pregnant; high B-vitamins generally safe during pregnancy.
Potential Side Effects
Negative Interactions
Allergens
Glucosamine (shellfish-derived potential)
Inactive Ingredients
Hypromellose (derived from cellulose)
Low RiskSilicon dioxide
Low RiskCalcium citrate
Low RiskCalcium laurate
Low RiskWhat Are the Ingredients in THORNE® Methyl-Guard®?
Vitamin B6 (as Pyridoxal 5'-Phosphate)
20.4 mg
Folate (1.2 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
2 mg DFE
Vitamin B12 (as Methylcobalamin)
1.2 mg
Betaine Anhydrous (Trimethylglycine)
1.8 g
Hypromellose (derived from cellulose)
Silicon Dioxide
Calcium Citrate
Calcium Laurate
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Dosage & Bioavailability
How the active doses and forms in Methyl-Guard® compare to the research.
•Formula — 4 actives: 2 over their upper limits (vitamin B6 20.4 mg and folate 2 mg), 1 above studied amounts (vitamin B12 1.2 mg) and 1 below studied amounts (betaine anhydrous 1.8 g).
•Vitamin B6 (as Pyridoxal 5'-Phosphate) — 20.4 mg per serving is over the 12 mg/day upper limit (EFSA 2023); the US limit is 100 mg/day (IOM (NIH ODS)).
•Vitamins and minerals — 3 of 3 provide at least 90% of the daily reference intake: vitamin B12 (about 480 times), vitamin B6 (about 12 times) and folate (about 5 times).
Frequently Asked Questions
Common questions about THORNE® Methyl-Guard®